![]() ![]() An average of 1.5–2.5 g of turmeric was estimated to be consumed by Asians in their daily diet which may correspond to about 60–100 mg of curcuminoids, the chief biologically active principle and yellow pigment of turmeric. Turmeric ( Curcuma Longa L.) is an age-old Asian Spice with more than 5000 years of history of usage in Indian traditional systems of medicine. CGM can be considered as a safe curcumin supplement for regular consumption and is devoid of any adulterants or contaminants. In summary, no adverse effects were observed under the conditions of the study. Liver function enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and bilirubin were in the normal range after 90-day supplementation of CGM. CGM supplementation did not cause any adverse effects or clinically significant variations in the vital signs, hematological parameters, lipid profile and renal function markers of the volunteers, indicating its safety. Twenty healthy human volunteers were evaluated for toxic manifestations of CGM when supplemented with 1000 mg per day (∼380 mg curcuminoids) for 90-days. The present study is an evaluation of the safety of curcumin-galactomannoside complex (CGM), a highly bioavailable curcumin formulation with demonstrated high free curcuminoids delivery. Considering these incidences and speculations, there is a need to critically evaluate the safety of curcumin supplements for prolonged intake. ![]() ![]() ![]() Even though no clear evidence was elucidated for the suspected toxicity, the addition of adjuvants that inhibits body’s essential detoxification pathways, adulteration with synthetic curcumin, and presence of contaminants including heavy metals, chromate, illegal dyes, non-steroidal anti-inflammatory agents, and pyrrole alkaloids were suggested as plausible reasons. Recently, there is a growing concern about the use of curcumin supplements owing to a few reported hepatotoxicity related adverse events among some of the long-term consumers. ![]()
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